Blood sugar dysregulation is one of the most prevalent metabolic conditions in the modern world, affecting an estimated 400 million people globally who have been diagnosed with type 2 diabetes and a further 400 million who have been diagnosed with pre-diabetes (impaired glucose tolerance). The fundamental problem in blood sugar dysregulation is insulin resistance — the failure of the insulin-signalling pathway in the muscle, fat, and liver cells to respond to the insulin that is secreted by the pancreatic beta cells, resulting in elevated blood glucose levels that, if sustained, produce the microvascular and macrovascular complications that are the primary causes of morbidity and mortality in diabetes. The management of blood sugar dysregulation has traditionally centred on pharmaceutical interventions — metformin, the sulfonylureas, the thiazolidinediones, the SGLT2 inhibitors, and the GLP-1 receptor agonists — but there is growing interest in the use of natural compounds that target the root causes of insulin resistance and that can be used alongside or instead of pharmaceutical therapies. Amiclear is a supplement that was formulated to address the multiple pathways that contribute to insulin resistance, combining seven superingredients that have been studied in clinical trials for their effects on blood sugar regulation and on insulin sensitivity.
The Seven Superingredients of Amiclear
Amiclear contains a proprietary blend of seven ingredients that have been selected for their specific effects on the multiple pathways of insulin resistance. The first is chromium, an essential trace element that is a component of the chromodulin protein, which amplifies the insulin signal at the insulin receptor by potentiating the autophosphorylation of the beta subunit of the receptor. Multiple RCTs have demonstrated that chromium supplementation at 200-500mcg daily reduces fasting blood glucose, reduces HbA1c, and improves insulin sensitivity in people with type 2 diabetes and with insulin resistance. The second is Gymnema sylvestre, an Ayurvedic herb that has been shown to reduce the intestinal absorption of glucose (by binding to the glucose receptors in the intestinal brush border), to stimulate the regeneration of the pancreatic beta cells, and to improve the sensitivity of the beta cells to the blood glucose signal. The third is banaba leaf extract (Lagerstroemia speciosa), which contains corosolic acid, a compound that has been shown to activate the glucose transporter type 4 (GLUT4) translocation to the cell membrane and to enhance the insulin-independent glucose uptake by muscle cells.
The fourth ingredient is bitter melon (Momordica charantia), which contains the polypeptide-p (an insulin-like compound that has been shown to reduce blood glucose levels in animal models and in human trials) and that has been used traditionally in Asian and Ayurvedic medicine for the management of diabetes for centuries. The fifth ingredient is alpha-lipoic acid (ALA), which has been shown to improve insulin sensitivity by activating the AMPK enzyme, by reducing the oxidative stress that impairs the insulin-signalling pathway, and by enhancing the translocation of GLUT4 to the cell membrane. The sixth ingredient is cinnamon bark extract (Cinnamomum cassia), which has been shown in multiple RCTs to reduce fasting blood glucose, to reduce HbA1c, and to improve insulin sensitivity in people with type 2 diabetes — the proposed mechanism involves the cinnamaldehyde component, which activates the insulin-signalling pathway and reduces the hepatic gluconeogenesis. The seventh ingredient is vanadium, a trace element that has been shown in clinical trials to have insulin-mimetic effects, activating the insulin-receptor kinase and inhibiting the protein tyrosine phosphatase 1B (PTP1B) enzyme that dephosphorylates and inactivates the insulin receptor.
The Clinical Evidence for Amiclear
The individual ingredients of Amiclear have been studied in multiple clinical trials, and the combination of these ingredients in the Amiclear formulation provides a multi-targeted approach to the management of insulin resistance and blood sugar dysregulation. A systematic review of the clinical evidence for chromium supplementation in type 2 diabetes found that chromium supplementation at 200-500mcg daily reduced fasting blood glucose by an average of 1.1 mmol/L (approximately 20mg/dL) and reduced HbA1c by an average of 0.6% — an effect size that is comparable to the effect of metformin in early type 2 diabetes. A meta-analysis of the clinical evidence for cinnamon bark extract in type 2 diabetes found that cinnamon supplementation at 1-6g daily reduced fasting blood glucose by an average of 0.5 mmol/L and reduced HbA1c by an average of 0.4% — again, an effect size that is clinically meaningful and that complements the effects of the other ingredients in the Amiclear formulation.
Real-World Results and Who Should Use Amiclear
Amiclear is designed for adults who have been diagnosed with pre-diabetes (impaired glucose tolerance, with fasting blood glucose of 100-125mg/dL or HbA1c of 5.7-6.4%) or with type 2 diabetes (fasting blood glucose of 126mg/dL or higher, or HbA1c of 6.5% or higher), and who want a natural supplement to support their blood sugar management alongside dietary and lifestyle changes and alongside their prescribed medications. Amiclear is particularly appropriate for people who have not yet been prescribed medication for their pre-diabetes or type 2 diabetes and who want to take a proactive approach to the management of their condition, and for people who are already taking pharmaceutical medications and who want to add a natural supplement to enhance their blood sugar control. Amiclear should not be used as a substitute for prescribed diabetes medications, and people who are taking diabetes medications should discuss the use of Amiclear with their healthcare provider to ensure that there are no clinically significant interactions (particularly with insulin secretagogues, which could theoretically increase the risk of hypoglycaemia when combined with Amiclear).
Practical Application
The recommended dose of Amiclear is one dropperful (approximately 1mL) taken three times daily, held under the tongue for 30 seconds before swallowing, which provides the equivalent of 200mcg chromium, 100mg Gymnema sylvestre extract, 50mg banaba leaf extract, 100mg bitter melon extract, 100mg alpha-lipoic acid, 250mg cinnamon bark extract, and 50mcg vanadium. For best results, Amiclear should be taken consistently for at least 8-12 weeks, as the improvements in insulin sensitivity and in blood sugar control take time to develop. Amiclear pairs well with the low-glycaemic-load dietary pattern (which reduces the demand on the pancreatic beta cells and supports the insulin-sensitising effects of the supplement), with the regular aerobic and resistance exercise programme (which is the most effective non-pharmacological intervention for the improvement of insulin sensitivity), and with the weight loss programme (which reduces the ectopic fat in the liver and the muscle that is the primary driver of insulin resistance).
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